![[E. coli graphic]](images/coli.gif){kind=small}
PCM-related Sites
- Steve Clarke's Web page
Dr. Clarke is a professor at UCLA's Molecular Biology Institute and the "father of PCM" - Claire O'Connor's Web page
Dr. O'Connor is a professor at Boston College studying PCM in Drosophila - Dana Aswad's Web page
Dr. Aswad is a professor at UC Irvine and studies isoaspartyl damage and repair of key cellular proteins
- PCM and lifespan in flies
Science News article on Claire O'Connor's work - Crystal structure of human PCM
- GenePage for pcm
from EcoGene - Protein folding and chaperones
from Lodish's Molecular Cell Biology - Overview of deamidation and isoAsp formation
- Deamidation.org
Methods for determining likelihood of Asp deamidation based on protein sequence and structure
- Altered levels of SAM and SAH in brains of PCM-deficient mice
Farrar and Clarke, JBC 277:27856 (2002) - Influence of protein structure on products of succinimide hydrolysis
Athmer et al., JBC 277:30502 (2002) - Crystal structure of human PCM
Ryttersgaard et al., JBC 277:10642 (2002) - PCM from the hyperthermophilic archaeon Pyrococcus furiosus
Thapar et al., JBC 277:1058 (2002) - Extension of Drosophila lifespan by overexpression of PCM
Chavous et al., PNAS 98:14814 (2001) - Deamidation of an MHC-bound peptide affects T-cell recognition
Cirrito et al., J. Exp. Med. 194:1165 (2001) - Structural integrity of histone H2B in vivo requires PCM
Young et al., JBC 276:37161 (2001) - Limited accumulation of damaged proteins in PCM-deficient mice
Lowenson et al., JBC 276:20695 (2001) - Distinct patterns of PCM expression in higher plants
Thapar et al., Plant Physiol. 125:1023 (2001) - Isoaspartyl post-translational modification triggers autoimmune response
Mamula et al., JBC 274:22321 (1999) - Phenotypic analysis of seizure-prone, PCM-deficient mice
Kim et al., JBC 274:20671 (1999) - Isoaspartate in ribosomal protein S11 of Escherichia coli
David et al., J. Bacteriol. 181:2872 (1999) - Methylation of deamidated calmodulin by PCM increases its stability in Xenopus oocytes
Szymanska et al., JBC 273:28516 (1998) - PCM enhances survival of aging E. coli subjected to environmental stresses
Visick et al., J. Bacteriol. 180:2623 (1998)
Some Useful Links